0001193125-06-167837 Sample Contracts

AMENDMENT NO. 2 to DEVELOPMENT AND LICENSE AGREEMENT between GLAXO GROUP LIMITED and ADHEREX TECHNOLOGIES INC.
Development and License Agreement • August 9th, 2006 • Adherex Technologies Inc • Biological products, (no disgnostic substances) • North Carolina

THIS AMENDMENT NO. 2 (this “Second Amendment”) effective on this 23rd day of June, 2006 (the “Second Amendment Effective Date”), is entered into by and between Glaxo Group Limited, a company organized under the laws of England and Wales, having its registered office at GlaxoWellcome House, Berkeley Avenue, Greenford, Middlesex, UB6 0NN United Kingdom (“GGL”) and Adherex Technologies Inc., a company organized under the laws of Canada and having an office located at 4620 Creekstone Drive, Suite 200, Durham, North Carolina, 27703 USA (“Adherex”):

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