0001193125-06-214006 Sample Contracts

ANGIOTECH PHARMACEUTICALS, INC. AND EACH OF THE GUARANTORS PARTY HERETO 7.75 % SENIOR SUBORDINATED NOTES DUE 2014
Indenture • October 25th, 2006 • Tercentenary Holdings, Corp. • Pharmaceutical preparations • New York

INDENTURE dated as of March 23, 2006 among Angiotech Pharmaceuticals, Inc., a corporation organized under the Business Corporations Act of the Province of British Columbia, the Guarantors (as defined) and Wells Fargo Bank, N.A., as trustee.

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OPERATING AGREEMENT OF CRIMSON CARDINAL CAPITAL, LLC, A NEVADA LIMITED LIABILITY COMPANY
Operating Agreement • October 25th, 2006 • Tercentenary Holdings, Corp. • Pharmaceutical preparations • Nevada

THIS OPERATING AGREEMENT is made as of the 20th day of February, 2006, by and among the members of Crimson Cardinal Capital, LLC, a Nevada limited liability company (the “Company”), all of whom have signed this operating agreement.

ANGIOTECH INVESTMENT PARTNERSHIP PARTNERSHIP AGREEMENT OCTOBER 28, 2004 Angiotech Pharmaceuticals, Inc. -and- 3091796 Nova Scotia Company
Partnership Agreement • October 25th, 2006 • Tercentenary Holdings, Corp. • Pharmaceutical preparations • British Columbia

NOW THEREFORE THIS AGREEMENT WITNESSES that for good and valuable consideration (the receipt and sufficiency of which is hereby acknowledged), the Partners mutually covenant and agree as follows:

OPERATING AGREEMENT OF ANGIOTECH CAPITAL, LLC A NEVADA LIMITED LIABILITY COMPANY
Operating Agreement • October 25th, 2006 • Tercentenary Holdings, Corp. • Pharmaceutical preparations • Nevada

THIS OPERATING AGREEMENT is made effective as of the 22nd day of October, 2002, by and between Angiotech Pharmaceuticals, Inc., a Canadian corporation, as the sole member of Angiotech Capital, LLC, a Nevada limited liability company (the “Company”), and the Company.

SUPPLEMENTAL INDENTURE
Supplemental Indenture • October 25th, 2006 • Tercentenary Holdings, Corp. • Pharmaceutical preparations • New York

Supplemental Indenture (this “Supplemental Indenture”), dated as of August 18, 2006, among Quill Medical, Inc. and 0761717 B.C. Ltd. (each a “Guaranteeing Subsidiary” and collectively, the “Guaranteeing Subsidiaries”), subsidiaries of Angiotech Pharmaceuticals, Inc. (or its permitted successor), a corporation organized under the Business Corporations Act of the Province of British Columbia (the “Company”), the other Guarantors (as defined in the Indenture referred to herein) and Wells Fargo Bank, N.A., as trustee under the Indenture referred to below (the “Trustee”).

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