0001193125-06-228165 Sample Contracts

SECOND AMENDMENT TO LOAN AND SECURITY AGREEMENT
Loan and Security Agreement • November 8th, 2006 • Nuvelo Inc • In vitro & in vivo diagnostic substances

THIS SECOND AMENDMENT to Loan and Security Agreement (this “Amendment”) is entered into this 29th day of August, 2006, by and between Silicon Valley Bank (“Bank”) and Nuvelo, Inc., a Delaware corporation (“Borrower”) whose address is 201 Industrial Road, Suite 310, San Carlos, CA 94070-6211.

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AMENDED AND RESTATED COLLABORATION AND LICENSE AGREEMENT
Collaboration and License Agreement • November 8th, 2006 • Nuvelo Inc • In vitro & in vivo diagnostic substances • New York

THIS STOCK PURCHASE AGREEMENT dated as of [ ] (the “Agreement”) is made by and between Archemix Corp., a Delaware corporation (the “Company”), and Nuvelo, Inc., a Delaware corporation (the “Purchaser”).

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