November 22, 2006 EXECUTION COPYAuxilium Pharmaceuticals Inc • November 29th, 2006 • Pharmaceutical preparations
Reference is made to Exhibit No. 11 to the Research and Development Agreement between Cobra Biomanufacturing Plc (“Cobra”) and Auxilium Pharmaceuticals, Inc. (“Auxilium”), dated July 14, 2006 (the “Agreement”). This letter agreement sets forth the terms and conditions upon which Cobra and Auxilium have mutually agreed to amend the Agreement. All capitalized terms used herein and not otherwise defined herein shall have the meanings ascribed to them in the Agreement. The Agreement (and all of its Appendices, including the Development Program Chart) is hereby amended as follows:
