0001193125-06-248749 Sample Contracts

AMENDMENT AND AGREEMENT
Amendment and Agreement • December 7th, 2006 • Indevus Pharmaceuticals Inc • Pharmaceutical preparations • Delaware

THIS AMENDMENT AND AGREEMENT (“Amendment”) is made as of November 3, 2006 (“Amendment Effective Date”) by and between Indevus Pharmaceuticals, Inc., a corporation organized and existing under the laws of the State of Delaware and having its principal office at 33 Hayden Avenue, Lexington, MA 02421, United States (“Indevus”), and Madaus GmbH, a successor to Madaus AG, a company with limited liability organized and existing under the laws of Germany and having its principal office at Colonia-Allee 15, 51067 Cologne, Germany (“Madaus”). Indevus and Madaus are collectively referred to herein as the “Parties”.

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API SUPPLY AGREEMENT
Api Supply Agreement • December 7th, 2006 • Indevus Pharmaceuticals Inc • Pharmaceutical preparations • New York

This API Supply Agreement (this “Agreement”) is made as of this 22nd day of November, 2006 (“Effective Date”), by and between INDEVUS PHARMACEUTICALS INC., a corporation organized and existing under the laws of the State of Delaware, United States of America, and having an office at 33 Hayden Avenue, Lexington, MA 02421-7971, United States (“Indevus”) and HELSINN CHEMICALS SA and HELSINN ADVANCED SYNTHESIS SA, both corporations organized and existing under the law of Switzerland and having their registered office at Via Industria 24, 6710 Biasca, Switzerland (“Helsinn”). Indevus and Helsinn hereinafter are collectively referred to as the “Parties” and individually as a “Party”.

LICENSE AND SUPPLY AGREEMENT by and between INDEVUS PHARMACEUTICALS, INC. and MADAUS GMBH
License and Supply Agreement • December 7th, 2006 • Indevus Pharmaceuticals Inc • Pharmaceutical preparations • Delaware

THIS LICENSE AND SUPPLY AGREEMENT is effective as of November 3, 2006 (“Effective Date”), by and between INDEVUS PHARMACEUTICALS, INC., a corporation organized and existing under the laws of the State of Delaware and having its principal office at 33 Hayden Avenue, Lexington, Massachusetts 02421, United States (“Indevus”), and MADAUS GmbH, a company with limited liability organized and existing under the laws of Germany and having its principal office at Colonia-Allee 15, 51067 Cologne, Germany (“Madaus”). Indevus and Madaus are collectively referred to herein as the “Parties”.

KNOW-HOW LICENSE AGREEMENT by and between INDEVUS PHARMACEUTICALS, INC. and NOVEXEL SA
Termination Agreement • December 7th, 2006 • Indevus Pharmaceuticals Inc • Pharmaceutical preparations • New York

THIS KNOW-HOW LICENSE AGREEMENT (“Agreement”) is effective as of December 4th, 2006 (“Effective Date”), by and between INDEVUS PHARMACEUTICALS, INC., a corporation organized and existing under the laws of the State of Delaware and having its principal office at 33 Hayden Avenue, Lexington, Massachusetts 02421, United States (“Indevus”), and NOVEXEL SA, a corporation organized and existing under the laws of France and having its principal office at Parc Biocitech, 102, route de Noisy, F-93230 Romainville France (“Novexel”). Indevus and Novexel are collectively referred to herein as the “Parties”, and individually, as a “Party”.

Manufacturing and Supply Agreement
Quality Assurance Agreement • December 7th, 2006 • Indevus Pharmaceuticals Inc • Pharmaceutical preparations • New York

WHEREAS, Schering and Indevus have entered into the License Agreement (hereinafter defined) regarding the development and commercialization of Product (hereinafter defined) in the Field (hereinafter defined) in the US by Indevus; and

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