0001193125-06-254745 Sample Contracts

AMENDMENT NO. 1 TO PURCHASE OPTION AGREEMENT
Purchase Option Agreement • December 18th, 2006 • Exelixis Inc • Services-commercial physical & biological research • New York

AMENDMENT NO. 1, dated December 14, 2006 (the “Amendment”), to the PURCHASE OPTION AGREEMENT, dated June 9, 2005 (the “Agreement”), by and among EXELIXIS, INC., a Delaware corporation (“Exelixis”), SYMPHONY EVOLUTION HOLDINGS LLC, a Delaware limited liability company (“Holdings”), and SYMPHONY EVOLUTION, INC., a Delaware corporation (“Symphony Evolution”). Terms used but not defined herein shall have that meaning ascribed to them in the Agreement.

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