0001193125-07-005411 Sample Contracts

AMENDMENT AGREEMENT
Strategic Alliance Agreement • January 11th, 2007 • Endo Pharmaceuticals Holdings Inc • Pharmaceutical preparations

This amendment (this “2007 Amendment”) to the Amended and Restated Strategic Alliance Agreement dated as of April 2, 2002 (the “2002 Agreement”) by and between PENWEST PHARMACEUTICALS CO., a corporation organized and existing under the laws of the State of Washington, with its principal place of business at 39 Old Ridgebury Road, Danbury, Connecticut 06810 (“Penwest”), and ENDO PHARMACEUTICALS INC., a corporation organized and existing under the laws of the State of Delaware, with its principal place of business at 100 Painters Drive, Chadds Ford, Pennsylvania 19317 (“Endo”), is entered into by and between Penwest and Endo this 7th day of January, 2007.

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