0001193125-07-055699 Sample Contracts

SECOND AMENDMENT TO THE LICENSE AGREEMENT BETWEEN THE REGENTS OF THE UNIVERSITY OF MICHIGAN (“MICHIGAN”; File Nos. 800, 800P1, 926, 926P1, 926P2, 926P3, 938, 1019, AND 1116) and SELECTIVE GENETICS, INC. (“SELECTIVE”)
License Agreement • March 15th, 2007 • Cardium Therapeutics, Inc. • Biological products, (no disgnostic substances)

This Amendment is to the Agreement between MICHIGAN and SELECTIVE (formerly Prizm Pharmaceuticals, Inc.; UM File Nos. 800, 800P1, 926, 926P1, 926P2, 926P3, 938, 1019, and 1116), which Agreement was effective July 13, 1995 between MICHIGAN and Matrigen, Inc. and which Agreement had been assigned by Matrigen, Inc. to Prizm Pharmaceuticals, Inc. in March of 1998.

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LICENSE AGREEMENT MICHIGAN FILE NOS. 800, 800p1, 926, 926p1, 926p2, 926p3, 938, 1019 and 1116 TECHNOLOGY
License Agreement • March 15th, 2007 • Cardium Therapeutics, Inc. • Biological products, (no disgnostic substances) • Michigan

This Agreement shall be effective as of the Effective Date noted above, and (notwithstanding Article 14) shall have a provisional term of exactly 30 days. During this term, MATRIGEN shall use its best efforts to demonstrate to MICHIGAN completion of the following:

Amendment 2
Cardium Therapeutics, Inc. • March 15th, 2007 • Biological products, (no disgnostic substances)
Amendment 1
Cardium Therapeutics, Inc. • March 15th, 2007 • Biological products, (no disgnostic substances)
THIRD AMENDMENT TO LICENSE AGREEMENT
License Agreement • March 15th, 2007 • Cardium Therapeutics, Inc. • Biological products, (no disgnostic substances)

This Third Amendment to License Agreement (“Amendment”), dated 10 August 2006 (“Amendment Date”), is by and among Tissue Repair Company (“LICENSEE”), the Regents of the University of Michigan (“MICHIGAN”) and Cardium Biologics, Inc. (“BUYER”).

LICENSE AGREEMENT AMENDMENT
License Agreement • March 15th, 2007 • Cardium Therapeutics, Inc. • Biological products, (no disgnostic substances)

This is an Agreement, effective as of the 10th day of August, 1995 (the “Effective Date”), between Matrigen, Inc., a corporation incorporated in the State of Delaware, with its principal place of business in the State of Michigan located at 425 North Main Street, Ann Arbor, MI 48104-4833 (“MATRIGEN”) , and the Regents of the University of Michigan, a constitutional corporation of the State of Michigan (“MICHIGAN”), amending the License Agreement completed by these parties entitled “LICENSE AGREEMENT / MICHIGAN FILE NOS. 800, 800p1, 926, 926p1, 926p2, 926p3, 938, 1019 and 1116 TECHNOLOGY,” and effective as of July 13, 1995 (the “License Agreement”). MATRIGEN and MICHIGAN agree as follows:

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