0001193125-07-108083 Sample Contracts

January 26, 2007 Corey S. Goodman, Ph.D. Oakland, California 94618 Re: Amended and Restated Employment Agreement Dear Corey:
Employment Agreement • May 9th, 2007 • Renovis Inc • Pharmaceutical preparations • California

You and Renovis, Inc. (the “Company”) are parties to an Employment Agreement dated June 8, 2001, as amended on May 1, 2003, amended and restated on April 8, 2005 and amended and restated on September 15, 2006 (the “Employment Agreement”), which sets forth, among other things, the terms of your employment with the Company and certain severance benefits payable to you in the event of a qualifying termination of your employment. This letter (the “Agreement”) amends and restates the Employment Agreement to provide you with additional benefits in the event of certain terminations of your employment in connection with a Change in Control (as defined below). This Agreement supersedes the Employment Agreement and any other agreement or policy to which the Company is a party with respect to your employment with the Company. Notwithstanding the foregoing, your Confidentiality and Proprietary Information Agreement remains in full effect.

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EXTENSION—AMENDMENT A TO THE COLLABORATIVE RESEARCH AGREEMENT
Collaborative Research Agreement • May 9th, 2007 • Renovis Inc • Pharmaceutical preparations

This AMENDMENT A to the COLLABORATIVE RESEARCH AGREEMENT of June 28, 2005 (the “Research Agreement”) for the extension through the Third Commitment Year of the research term is entered into as of March 30, 2007 between:

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