0001193125-07-247479 Sample Contracts

OFFICE LEASE BETWEEN PASEO DEL MAR CA, LLC (“LANDLORD”) AND CARDIUM THERAPEUTICS, INC. (“TENANT”)
Office Lease • November 14th, 2007 • Cardium Therapeutics, Inc. • Biological products, (no disgnostic substances)

This Office Lease (this “Lease”) is entered into by and between PASEO DEL MAR CA, LLC, a Delaware limited liability company (“Landlord”), and CARDIUM THERAPEUTICS, INC., a Delaware corporation (“Tenant”), and shall be effective as of the date set forth below Landlord’s signature (the “Effective Date”).

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LOAN AND SECURITY AGREEMENT
Loan and Security Agreement • November 14th, 2007 • Cardium Therapeutics, Inc. • Biological products, (no disgnostic substances)

LOAN AND SECURITY AGREEMENT (this “Agreement”), dated as of November 12, 2007, among LIFE SCIENCES CAPITAL, LLC (together with its successors and assigns, if any, “Lender”), InnerCool Therapies, Inc., a Delaware corporation (“InnerCool”), Tissue Repair Company, a Delaware corporation (“TRC”), and Cardium Therapeutics, Inc., a Delaware corporation (“Cardium” and, together with InnerCool and TRC, individually, a “Borrower,” and collectively, the “Borrowers”). Lender has an office at 6 East 43rd Street, New York, New York 10017, and the chief executive office and place of business of each of the Borrowers is 3611 Valley Centre, Suite 525, San Diego, California 92130.

SECURED PROMISSORY NOTE
Cardium Therapeutics, Inc. • November 14th, 2007 • Biological products, (no disgnostic substances)

FOR VALUE RECEIVED, INNERCOOL THERAPIES, INC., TISSUE REPAIR COMPANY, AND CARDIUM THERAPEUTICS, INC., each having an address as set forth below (individually, a “Borrower,” and collectively, the “Borrowers”), jointly and severally promise to pay to the order of Life Sciences Capital LLC or any subsequent holder hereof (each, a “Lender”) at its office located at 6 East 43rd Street, New York, New York 10017, or at such other place as Lender may from time to time designate, the principal sum of Five Million and 00/100 Dollars ($5,000,000.00), with interest on the unpaid principal balance (computed based on a year of 360 days), from the date hereof through and including the dates of payment, at a fixed interest rate of nine and eight one-hundredths percent (9.08%) per annum, payable (x) in 35 consecutive monthly payments of principal and interest in the amount of one hundred fifty-nine thousand one hundred eighty-four and 89/100 Dollars ($159,184.89) each, payable in arrears on the first d

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