0001193125-08-043467 Sample Contracts

LICENSE AND COLLABORATION AGREEMENT dated as of December 4, 2007 by and between ADOLOR CORPORATION and PFIZER INC.
License and Collaboration Agreement • February 29th, 2008 • Adolor Corp • Pharmaceutical preparations • New York

THIS LICENSE AND COLLABORATION AGREEMENT (the “Agreement”), dated as of December 4, 2007 (the “Effective Date”), is made by and between Adolor Corporation, a corporation organized and existing under the laws of the State of Delaware and having its principal office at 700 Pennsylvania Drive, Exton, Pennsylvania 19341 (“Adolor”), and Pfizer Inc., a corporation organized and existing under the laws of the State of Delaware and having its principal office at 235 East 42nd Street, New York, New York 10017-5755 (“Pfizer”). Adolor and Pfizer are sometimes referred to herein individually as a “Party” and collectively as the “Parties.”

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February 21, 2008 Mr. Michael R. Dougherty Dear Mr. Dougherty,
Adolor Corp • February 29th, 2008 • Pharmaceutical preparations

This letter (this “Third Amendment”) will amend that certain letter agreement dated October 24, 2002, between you and Adolor Corporation (the “Company”) (the “Letter Agreement”), as amended January 26, 2004 (the “First Amendment”), as amended December 14, 2006 (the “Second Amendment”) a copy of the Letter Agreement, the First Amendment and the Second Amendment are appended to this letter as Exhibit A. The Letter Agreement, First Amendment, Second Amendment and this Third Amendment shall together constitute the “Agreement”).

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