0001193125-08-107393 Sample Contracts

Re: Amendment No. 2 to the Stock and Note Purchase Agreement

Stock and Note Purchase Agreement • May 8th, 2008 • GTC Biotherapeutics Inc • Biological products, (no disgnostic substances) • Massachusetts

• Contract Type
  Stock and Note Purchase Agreement
• Filed
  May 8th, 2008
• Company
  GTC Biotherapeutics Inc
• Industry
  Biological products, (no disgnostic substances)
• Jurisdiction
  Massachusetts

This letter sets forth a second amendment to the Stock and Note Purchase Agreement dated as of September 29, 2006 between LFB Biotechnologies (the “Purchaser”) and GTC Biotherapeutics, Inc. (the “Company”), as amended by the amendment dated October 18, 2006 (as previously amended, the “Agreement”). This amendment shall be interpreted in accordance with the terms of the Agreement. Capitalized terms not defined herein shall have the meanings set forth in the Agreement.

LFB Biotechnologies 3, avenue des Tropiques Les Ulis 91958 Courtaboeuf France Re: Amendment to the Stock and Note Purchase Agreement

Stock and Note Purchase Agreement • May 8th, 2008 • GTC Biotherapeutics Inc • Biological products, (no disgnostic substances)

• Contract Type
  Stock and Note Purchase Agreement
• Filed
  May 8th, 2008
• Company
  GTC Biotherapeutics Inc
• Industry
  Biological products, (no disgnostic substances)

This letter sets forth an amendment to the Stock and Note Purchase Agreement dated as of September 29, 2006 (the “Agreement”) between LFB Biotechnologies (the “Purchaser”) and GTC Biotherapeutics, Inc. (the “Company”) and shall be interpreted in accordance with the terms thereof. Capitalized terms not defined herein shall have the meanings set forth in the Agreement.