0001193125-08-248941 Sample Contracts

RESIGNATION AGREEMENT
Resignation Agreement • December 5th, 2008 • Orexigen Therapeutics, Inc. • Pharmaceutical preparations • California

This Resignation Agreement (“Agreement”) is hereby entered into by and between Orexigen Therapeutics, Inc., a Delaware corporation (the “Company”), and Gary D. Tollefson, M.D., Ph.D. (“Executive”). The Company and Executive are sometimes referred to herein as a “Party” or collectively as the “Parties.”

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