0001193125-09-066121 Sample Contracts

AMENDED AND RESTATED EMPLOYMENT AGREEMENT
Employment Agreement • March 27th, 2009 • TorreyPines Therapeutics, Inc. • Pharmaceutical preparations • California

This AMENDED AND RESTATED EMPLOYMENT AGREEMENT (the “Agreement”) is entered into effective as of November 12, 2008 (the “Effective Date”), by and between TorreyPines Therapeutics, Inc. (the “Parent”) Parent’s subsidiary, TPTX, Inc. (“TPTX”) and Paul Schneider (the “Executive”). As used in this Agreement, references to the “Company” shall include the Parent and TPTX, as appropriate. This Agreement shall replace and supersede that certain Employment Agreement between Executive and the Company entered into effective as of February 1, 2007 (the “Prior Agreement”). The Company and the Executive are hereinafter collectively referred to as the “Parties,” and individually referred to as a “Party.”

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FIRST AMENDMENT TO LEASE
Lease Agreement • March 27th, 2009 • TorreyPines Therapeutics, Inc. • Pharmaceutical preparations

This FIRST AMENDMENT TO LEASE (“Amendment”) is made and entered into as of the 7th day of January, 2009, by and between HCP TPSP, LLC, a Delaware limited liability company (“Landlord”), and TORREYPINES THERAPEUTICS, INC., a Delaware corporation (“Tenant”).

AMENDMENT TO EMPLOYMENT AGREEMENT
Employment Agreement • March 27th, 2009 • TorreyPines Therapeutics, Inc. • Pharmaceutical preparations

THIS AMENDMENT TO EMPLOYMENT AGREEMENT (the “Amendment”) is made and entered into as of February 3, 2009 by and between TorreyPines Therapeutics, Inc. (the “Parent”), Parent’s subsidiary, TPTX, Inc. (“TPTX”) and PAUL SCHNEIDER (“Executive”). As used in this Amendment, references to the “Company” shall include the Parent and TPTX, as appropriate. Capitalized terms used but not defined herein shall have the meaning assigned to them in the Agreement (as defined below).

AMENDMENT TO EMPLOYMENT AGREEMENT
Employment Agreement • March 27th, 2009 • TorreyPines Therapeutics, Inc. • Pharmaceutical preparations

THIS AMENDMENT TO EMPLOYMENT AGREEMENT (the “Amendment”) is made and entered into as of February 3, 2009 by and between TorreyPines Therapeutics, Inc. (the “Parent”), Parent’s subsidiary, TPTX, Inc. (“TPTX”) and EVELYN GRAHAM (“Executive”). As used in this Amendment, references to the “Company” shall include the Parent and TPTX, as appropriate. Capitalized terms used but not defined herein shall have the meaning assigned to them in the Agreement (as defined below).

AMENDMENT TO DEVELOPMENT AND LICENSE AGREEMENT
Development and License Agreement • March 27th, 2009 • TorreyPines Therapeutics, Inc. • Pharmaceutical preparations • California

This AMENDMENT TO DEVELOPMENT AND LICENSE AGREEMENT (this “Amendment”) dated this 21st day of November, 2008 (the “Effective Date”), is entered into between TPTX, Inc. (f/k/a Neurogenetics, Inc.), a Delaware corporation having its principal place of business at 11085 North Torrey Pines Road, Suite 300, CA 92037 and its Affiliates (collectively “TPTX”) and Eli Lilly and Company, an Indiana corporation having an office and principal place of business at Lilly Corporate Center, Indianapolis, Indiana 46285 and its Affiliates (“Lilly”). Capitalized terms used but not defined herein shall have the meaning assigned to them in the Agreement (as defined below).

AMENDMENT TO EMPLOYMENT AGREEMENT
Employment Agreement • March 27th, 2009 • TorreyPines Therapeutics, Inc. • Pharmaceutical preparations

THIS AMENDMENT TO EMPLOYMENT AGREEMENT (the “Amendment”) is made and entered into as of February 3, 2009 by and between TorreyPines Therapeutics, Inc. (the “Parent”), Parent’s subsidiary, TPTX, Inc. (“TPTX”) and CRAIG JOHNSON (“Executive”). As used in this Amendment, references to the “Company” shall include the Parent and TPTX, as appropriate. Capitalized terms used but not defined herein shall have the meaning assigned to them in the Agreement (as defined below).

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