0001193125-09-077237 Sample Contracts

THIRD AMENDMENT TO LOAN AND SECURITY AGREEMENT
Loan and Security Agreement • April 10th, 2009 • ARCA Biopharma, Inc. • In vitro & in vivo diagnostic substances

THIS THIRD AMENDMENT to Loan and Security Agreement (this “Amendment”) is entered into this 6th day of April, 2009, by and between Silicon Valley Bank (“Bank”) and ARCA biopharma Colorado, Inc. (f/k/a ARCA biopharma, Inc.), a Delaware corporation (“Borrower”) whose address is 8001 Arista Place, Suite 200, Broomfield, CO 80021.

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FOURTH AMENDMENT TO AND ASSUMPTION OF LOAN AND SECURITY AGREEMENT
Loan and Security Agreement • April 10th, 2009 • ARCA Biopharma, Inc. • In vitro & in vivo diagnostic substances

THIS FOURTH AMENDMENT TO AND ASSUMPTION of Loan and Security Agreement (this “Amendment”) is entered into this 10th day of April, 2009, by and between Silicon Valley Bank (“Bank”) and ARCA biopharma Colorado, Inc. (“ARCA Colorado”), a Delaware corporation and ARCA biopharma, Inc., a Delaware corporation (“ARCA” and together with ARCA Colorado, individually and collectively, the “Borrower”) whose address is 8001 Arista Place, Suite 200, Broomfield, CO 80021.

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