0001193125-10-053929 Sample Contracts

Contract
Supply Agreement • March 11th, 2010 • Targacept Inc • Pharmaceutical preparations • New York

[********] Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

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NORTH CAROLINA ) ) FOURTH LEASE AMENDMENT FORSYTH COUNTY )
Fourth Lease Amendment • March 11th, 2010 • Targacept Inc • Pharmaceutical preparations

This Fourth Lease Amendment (the “Fourth Amendment”) is made effective as of the 1st day of August, 2007 (the “Amendment Date”), by and between Wake Forest University Health Sciences, a North Carolina non-profit corporation having its principal office in Winston-Salem, North Carolina (“Landlord”), and Targacept, Inc., a Delaware corporation having its principal office in Winston-Salem, North Carolina (“Tenant”). Unless otherwise defined herein, all of the capitalized terms of this Fourth Amendment shall have the same meanings ascribed to them in the Lease effective August 1, 2002, as amended by the First Lease Amendment effective January 1, 2005 (the “First Lease Amendment”), the Second Lease Amendment effective March 31, 2006 (the “Second Lease Amendment”), and the Third Lease Amendment effective January 1, 2007 (the “Third Lease Amendment”) all of which are hereinafter collectively referred to as the “Lease.”

COLLABORATION AND LICENSE AGREEMENT BETWEEN ASTRAZENECA AB AND TARGACEPT, INC.
Collaboration and License Agreement • March 11th, 2010 • Targacept Inc • Pharmaceutical preparations • New York

This COLLABORATION AND LICENSE AGREEMENT (this “Agreement”) is entered into as of the third day of December 2009 (the “Execution Date”) by and between Targacept, Inc., a Delaware corporation having its principal place of business at 200 East First Street, Winston-Salem, North Carolina 27101 (“Targacept”), and AstraZeneca AB, a company limited by shares organized and existing under the laws of Sweden having a principal place of business at V-Malarehamnen 9, S-151 85 Södertälje, Sweden (“AstraZeneca”). Targacept and AstraZeneca are each referred to herein by name or as a “Party” or, collectively, as the “Parties.”

NORTH CAROLINA ) ) FIFTH LEASE AMENDMENT FORSYTH COUNTY )
Lease Amendment • March 11th, 2010 • Targacept Inc • Pharmaceutical preparations

This Fifth Lease Amendment (this “Fifth Amendment”), made effective as of the 1st day of October, 2009 (the “Amendment Date”), by and between Wake Forest University Health Sciences, a North Carolina non-profit corporation having its principal office in Winston-Salem, North Carolina (“Landlord”), and Targacept, Inc., a Delaware corporation having its principal office in Winston-Salem, North Carolina (“Tenant”), amends that certain Lease effective August 1, 2002, as amended by the First Lease Amendment effective January 1, 2005, the Second Lease Amendment effective March 31, 2006, the Third Lease Amendment effective January 1, 2007 and the Fourth Lease Amendment effective August 1, 2007 (the “Lease”).

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