0001193125-10-054939 Sample Contracts

ATryn Generation I Clinical and Commercial SERVICE AGREEMENT
Service Agreement • March 12th, 2010 • GTC Biotherapeutics Inc • Biological products, (no disgnostic substances) • Massachusetts

LONZA Sales Ltd, a company organized and existing under the laws of Switzerland, established and having an office at Muenchensteinerstrasse 38, CH-4002 Basel, Switzerland, Europe (“LONZA”), and

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Contract
Secured Convertible Note • March 12th, 2010 • GTC Biotherapeutics Inc • Biological products, (no disgnostic substances) • Massachusetts

THIS NOTE AND THE SHARES OF CAPITAL STOCK ISSUED UPON ANY CONVERSION HEREOF HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR ANY APPLICABLE STATE SECURITIES LAWS AND MAY NOT BE SOLD OR OTHERWISE TRANSFERRED BY ANY PERSON, INCLUDING A PLEDGEE, UNLESS (1) EITHER (A) A REGISTRATION WITH RESPECT THERETO SHALL BE EFFECTIVE UNDER THE SECURITIES ACT, OR (B) THE COMPANY SHALL HAVE RECEIVED AN OPINION OF COUNSEL SATISFACTORY TO THE COMPANY THAT AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT IS AVAILABLE, AND (2) THERE SHALL HAVE BEEN COMPLIANCE WITH ALL APPLICABLE STATE SECURITIES OR “BLUE SKY” LAWS.

SERVICES AGREEMENT
Services Agreement • March 12th, 2010 • GTC Biotherapeutics Inc • Biological products, (no disgnostic substances)

THESE TERMS AND CONDITIONS are agreed to as of this 16th day of July, 2009 (the “Effective Date”) by and between GTC Biotherapeutics, Inc., a Massachusetts corporation with a business address at 175 Crossing Boulevard, Framingham, Massachusetts 01702 (“GTC”) and LFB Biotechnologies S.A.S. a Sociétée par Actions Simplifiée, having offices at 3, avenue des Tropiques, es Ulis, 91940 Courtaboeuf, France (“LFB”). GTC and LFB are sometimes referred to herein individually as a “Party” and collectively as the “Parties.”

OMNIBUS AMENDMENT REGARDING LOAN AGREEMENT
Loan Agreement • March 12th, 2010 • GTC Biotherapeutics Inc • Biological products, (no disgnostic substances)

This OMNIBUS AMENDMENT (this “Amendment”) dated December 21, 2009 is entered into by and between LFB Biotechnologies S.A.S. (the “Purchaser”) and GTC Biotherapeutics, Inc. (the “Company”).

OMNIBUS AMENDMENT REGARDING NOTE AND WARRANT PURCHASE AGREEMENT
Note and Warrant Purchase Agreement • March 12th, 2010 • GTC Biotherapeutics Inc • Biological products, (no disgnostic substances)

This OMNIBUS AMENDMENT (this “Amendment”) dated December 21, 2009 is entered into by and between LFB Biotechnologies S.A.S. (the “Purchaser”) and GTC Biotherapeutics, Inc. (the “Company”).

SECOND AMENDMENT TO MORTGAGE, SECURITY AGREEMENT AND FIXTURE FILING
Mortgage, Security Agreement and Fixture Filing • March 12th, 2010 • GTC Biotherapeutics Inc • Biological products, (no disgnostic substances)

THIS SECOND AMENDMENT TO MORTGAGE, SECURITY AGREEMENT AND FIXTURE FILING (this “Amendment”) is made as of the 21st day of December, 2009, by and between GTC BIOTHERAPEUTICS, INC., a Massachusetts corporation, formerly known as GENZYME TRANSGENICS CORPORATION, having an address of 175 Crossing Boulevard, Suite 410, Framingham, Massachusetts 01702 (the “Grantor”), and LFB BIOTECHNOLOGIES S.A.S.U., having an address of 3, avenue des Tropiques, LES ULIS, 91940 Courtaboeuf - FRANCE (the “Grantee”).

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