0001193125-10-058356 Sample Contracts

AMENDMENT NO. 2 TO THE TOLL MANUFACTURING AGREEMENT
Toll Manufacturing Agreement • March 16th, 2010 • Arena Pharmaceuticals Inc • Pharmaceutical preparations

This Amendment No. 2 (the “Amendment”), effective September 17, 2009, is by and between Arena Pharmaceuticals GmbH (“Arena”) and Siegfried Ltd. (“Siegfried”), and modifies the Toll Manufacturing Agreement, dated January 7, 2008, as amended, by and between Arena and Siegfried (the “Agreement”). All capitalized terms used herein and not otherwise defined shall have the meanings set forth in the Agreement.

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