0001193125-10-117490 Sample Contracts

AGREEMENT
Agreement • May 12th, 2010 • Combinatorx, Inc • Pharmaceutical preparations • New York

THIS AGREEMENT is entered into on and as of February 10, 2010 (the “Effective Date”), by and among Mallinckrodt Inc., a Covidien company (“Mallinckrodt”), ALZA Corporation (“ALZA”) and Neuromed Pharmaceuticals Ltd., a wholly owned subsidiary of CombinatoRx, Incorporated (“Neuromed”).

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January 14, 2010
Combinatorx, Inc • May 12th, 2010 • Pharmaceutical preparations

As the parties have agreed, you separated from your employment with CombinatoRx, Incorporated (the “Company”) as its Executive Vice President and Chief Operating Officer and as a member of its Board of Directors, effective as of January 5, 2010 (the “Separation Date”). The purpose of this letter is to confirm the agreement between you and the Company concerning your severance arrangements (the “Agreement”), as follows:

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