0001193125-10-183422 Sample Contracts

AMENDMENT NO. 3 TO COLLABORATIVE RESEARCH AND LICENSE AGREEMENT
Collaborative Research and License Agreement • August 9th, 2010 • Targacept Inc • Pharmaceutical preparations

This Amendment No. 3 to Collaborative Research and License Agreement (this “Amendment”), effective as of the date of signature of the last Party to sign below, amends the Collaborative Research and License Agreement entered into as of December 27, 2005 by and between AstraZeneca AB, a company limited by shares organized and existing under the laws of Sweden (“AstraZeneca”), and Targacept, Inc., a Delaware (USA) corporation (“Targacept”), as amended by Amendment No. 1 dated November 10, 2006 and Amendment No. 2 effective July 8, 2009 (the “Agreement”). Capitalized terms used herein and not otherwise defined shall have the meanings ascribed to them in the Agreement.

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NORTH CAROLINA ) ) SIXTH LEASE AMENDMENT FORSYTH COUNTY )
Sixth Lease Amendment • August 9th, 2010 • Targacept Inc • Pharmaceutical preparations

This Sixth Lease Amendment (this “Sixth Amendment”), made effective as of the date of signature of the last party to sign below (the “Amendment Date”), by and between Wake Forest University Health Sciences, a North Carolina non-profit corporation having its principal office in Winston-Salem, North Carolina (“Landlord”), and Targacept, Inc., a Delaware corporation having its principal office in Winston-Salem, North Carolina (“Tenant”), amends that certain Lease effective August 1, 2002, as amended by the First Lease Amendment effective January 1, 2005, the Second Lease Amendment effective March 31, 2006, the Third Lease Amendment effective January 1, 2007, the Fourth Lease Amendment effective August 1, 2007 and the Fifth Lease Amendment effective October 1, 2009 (the “Lease”). Unless otherwise defined herein, all of the capitalized terms of this Sixth Amendment shall have the respective meanings ascribed to them in the Lease.

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