0001193125-10-183456 Sample Contracts

SUPPLEMENTAL INDENTURE
Supplemental Indenture • August 9th, 2010 • Angiotech Pharmaceuticals Inc • Surgical & medical instruments & apparatus • New York

SUPPLEMENTAL INDENTURE (this “Supplemental Indenture”), dated as of June 8, 2010, among Angiotech America, Inc. and Angiotech Florida Holdings, Inc. (each, a “Guaranteeing Subsidiary” and, collectively, the “Guaranteeing Subsidiaries”), subsidiaries of Angiotech Pharmaceuticals, Inc. (or its permitted successor), a corporation organized under the Business Corporations Act of the Province of British Columbia (the “Company”), the Company, the other Guarantors (as defined in the Indenture referred to herein) and Deutsche Bank National Trust Company, as successor to Wells Fargo Bank, N.A., as trustee under the Indenture referred to below (the “Trustee”).

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THE SYMBOL ‘***’ IS USED THROUGHOUT THIS EXHIBIT TO INDICATE THAT A PORTION OF THE EXHIBIT HAS BEEN OMITTED AS CONFIDENTIAL. MAY 20, 2010 AMENDMENT BETWEEN ANGIOTECH PHARMACEUTICALS, INC. AND COOK INCORPORATED MODIFYING JULY 9, 1997 LICENSE AGREEMENT...
License Agreement • August 9th, 2010 • Angiotech Pharmaceuticals Inc • Surgical & medical instruments & apparatus

This Amendment is made and entered into as of this 20th day of May, 2010, by and between Angiotech Pharmaceuticals, Inc., a corporation organized under the laws of the Province of British Columbia (“Angiotech”) and Cook Incorporated, an Indiana corporation (“Cook”).

SUPPLEMENTAL INDENTURE
Supplemental Indenture • August 9th, 2010 • Angiotech Pharmaceuticals Inc • Surgical & medical instruments & apparatus • New York

SUPPLEMENTAL INDENTURE (this “Supplemental Indenture”), dated as of June 8, 2010, among Angiotech America, Inc. and Angiotech Florida Holdings, Inc. (each, a “Guaranteeing Subsidiary” and, collectively, the “Guaranteeing Subsidiaries”), subsidiaries of Angiotech Pharmaceuticals, Inc. (or its permitted successor), a corporation organized under the Business Corporations Act of the Province of British Columbia (the “Company”), the Company, the other Guarantors (as defined in the Indenture referred to herein) and Deutsche Bank National Trust Company, as successor to Wells Fargo Bank, N.A., as trustee under the Indenture referred to below (the “Trustee”).

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