0001193125-10-184932 Sample Contracts

SECOND AMENDED AND RESTATED COLLABORATION AND LICENSE AGREEMENT
Collaboration and License Agreement • August 10th, 2010 • ARCA Biopharma, Inc. • In vitro & in vivo diagnostic substances • New York

THIS SECOND AMENDED AND RESTATED COLLABORATION AND LICENSE AGREEMENT (the “Agreement”) is entered into and made effective as of April 20, 2010 (the “Amendment Effective Date”), by and between ARCA biopharma, Inc. a Delaware corporation having its principal place of business at 8001 Arista Place, Suite 200, Broomfield, CO 80021 (successor-in-interest to NUVELO, INC., a Delaware corporation having its principal place of business at 201 Industrial Road, Suite 310, San Carlos, CA 94070) (“ARCA”), and ARCHEMIX CORP., a Delaware corporation having its principal place of business at 300 Third Street, Cambridge, MA 02142 (“Archemix”). ARCA and Archemix are sometimes referred to herein individually as a “Party” and collectively as the “Parties.”

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