0001193125-10-252736 Sample Contracts

GTC BIOTHERAPEUTICS, INC. AND AMERICAN STOCK TRANSFER AND TRUST COMPANY LLC AS RIGHTS AGENT AMENDMENT No. 4 TO SHAREHOLDER RIGHTS AGREEMENT
Shareholder Rights Agreement • November 9th, 2010 • GTC Biotherapeutics Inc • Biological products, (no disgnostic substances) • Massachusetts

This Fourth Amendment to Shareholder Rights Agreement dated as of November 8, 2010 (the “Amendment”) is between GTC Biotherapeutics, Inc., a Massachusetts corporation formerly known as Genzyme Transgenics Corporation (the “Company”), and American Stock Transfer & Trust Company LLC, a banking organization organized under the laws of New York, as Rights Agent (the “Rights Agent”).

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STOCK PURCHASE AND MERGER AGREEMENT by and among GTC Biotherapeutics, Inc. LFB Biotechnologies S.A.S. and LFB Merger Sub, Inc. November 8, 2010
Stock Purchase and Merger Agreement • November 9th, 2010 • GTC Biotherapeutics Inc • Biological products, (no disgnostic substances) • Massachusetts

This Stock Purchase and Merger Agreement (this “Agreement”) dated as of November 8, 2010 is made by and between GTC Biotherapeutics, Inc., a Massachusetts corporation (the “Company”), LFB Biotechnologies S.A.S., a société par actions simplifiée established under the laws of France (“Parent”) and LFB Merger Sub, Inc., a Massachusetts corporation and wholly-owned subsidiary of Parent (“Merger Sub”).

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