0001193125-10-277503 Sample Contracts

BIO-RAD LABORATORIES, INC.
Global Note • December 9th, 2010 • Bio Rad Laboratories Inc • Laboratory analytical instruments

THIS GLOBAL NOTE IS HELD BY THE DEPOSITARY (AS DEFINED IN THE FIRST SUPPLEMENTAL INDENTURE GOVERNING THIS NOTE) OR ITS NOMINEE IN CUSTODY FOR THE BENEFIT OF THE BENEFICIAL OWNERS HEREOF, AND IS NOT TRANSFERABLE TO ANY PERSON UNDER ANY CIRCUMSTANCES EXCEPT THAT (I) THE TRUSTEE MAY MAKE SUCH NOTATIONS HEREON AS MAY BE REQUIRED PURSUANT TO SECTION 3.02 OF THE FIRST SUPPLEMENTAL INDENTURE, (II) THIS GLOBAL NOTE MAY BE EXCHANGED IN WHOLE BUT NOT IN PART PURSUANT TO SECTION 3.02(a) OF THE FIRST SUPPLEMENTAL INDENTURE, (III) THIS GLOBAL NOTE MAY BE DELIVERED TO THE TRUSTEE FOR CANCELLATION PURSUANT TO SECTION 2.12 OF THE BASE INDENTURE AND (IV) THIS GLOBAL NOTE MAY BE TRANSFERRED TO A SUCCESSOR DEPOSITARY WITH THE PRIOR WRITTEN CONSENT OF THE COMPANY.

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BIO-RAD LABORATORIES, INC. as Issuer and WILMINGTON TRUST FSB as Trustee FIRST SUPPLEMENTAL INDENTURE Dated as of December 9, 2010 to the Indenture dated as of December 9, 2010 4.875% Senior Notes due 2020
First Supplemental Indenture • December 9th, 2010 • Bio Rad Laboratories Inc • Laboratory analytical instruments • New York

FIRST SUPPLEMENTAL INDENTURE (this “First Supplemental Indenture”), dated as of December 9, 2010, between BIO-RAD LABORATORIES, INC., a Delaware corporation (the “Company”), and WILMINGTON TRUST FSB, as Trustee (the “Trustee”).

Bio-Rad Laboratories, Inc. UNDERWRITING AGREEMENT
Underwriting Agreement • December 9th, 2010 • Bio Rad Laboratories Inc • Laboratory analytical instruments • New York
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