0001193125-10-287308 Sample Contracts

SUPPLEMENTAL INDENTURE
Supplemental Indenture • December 23rd, 2010 • Angiotech Pharmaceuticals Inc • Surgical & medical instruments & apparatus • New York

SUPPLEMENTAL INDENTURE (this “Supplemental Indenture”), dated as of December 21, 2010, among Angiotech Pharmaceuticals, Inc., a corporation organized under the Business Corporation Act of the Province of British Columbia (the “Company”), the Guarantors under the Indenture (as defined and referred to below) and U.S. Bank National Association, as successor to Deutsche Bank National Trust Company, successor to Wells Fargo Bank, N.A., as trustee (the “Trustee”) under the Indenture. All capitalized terms used but not otherwise defined herein shall have the meaning assigned thereto in the Indenture.

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