0001193125-11-002959 Sample Contracts

Amarin Corporation plc 12,000,000 American Depositary Shares Representing 12,000,000 Ordinary Shares (Par Value £0.50 Per Share) UNDERWRITING AGREEMENT
Underwriting Agreement • January 6th, 2011 • Amarin Corp Plc\uk • Pharmaceutical preparations • New York

The ADSs will be evidenced by American depositary receipts (the “ADRs”) to be issued pursuant to a deposit agreement dated as of March 29, 1993, as amended by Amendment No. 1 to Deposit Agreement, dated as of October 8, 1998, and by Amendment No. 2 to Deposit Agreement, by and among the Company, Citibank, N.A., as depositary (the “Depositary”), and the holders from time to time of the American Depositary Receipts evidencing ADSs issued thereunder, as supplemented by letter agreements dated as of March 29, 2006, April 11, 2006, September 28, 2007, October 16, 2007, December 5, 2007, May 16, 2008, August 5, 2009, October 7, 2009, and October 15, 2009, each by and between the Company and the Depositary (the Deposit Agreement, dated March 29, 1993, as so amended and supplemented, the “Deposit Agreement”).

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