0001193125-11-036881 Sample Contracts

EMPLOYMENT AGREEMENT
Employment Agreement • February 15th, 2011 • Ampio Pharmaceuticals, Inc. • Pharmaceutical preparations • Colorado

This Employment Agreement (the “Agreement”), is effective as of August 1, 2010 (the “Effective Date”), and executed August 23, 2010, between Ampio Pharmaceuticals, Inc., a Delaware corporation headquartered at 8400 East Crescent Parkway, Suite 600, Greenwood Village, CO 80111 USA, hereinafter referred to as the “Company”), and Vaughan Clift, M.D. (“Employee”).

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AMENDMENT TO EMPLOYMENT AGREEMENT
Employment Agreement • February 15th, 2011 • Ampio Pharmaceuticals, Inc. • Pharmaceutical preparations

This Amendment to Employment Agreement (the “Amendment”), is effective as of October 1, 2010 (the “Effective Date”) between Ampio Pharmaceuticals, Inc., a Delaware corporation headquartered at 5445 DTC Parkway, PH 4, Greenwood Village, CO 80111, (hereinafter referred to as the “Company”), and Vaughan Clift, M.D. (“Employee”).

AMPIO PHARMACEUTICALS, INC. NOTE EXTENSION AND SUBORDINATION AGREEMENT
Note Extension and Subordination Agreement • February 15th, 2011 • Ampio Pharmaceuticals, Inc. • Pharmaceutical preparations

On June 23, 2010, the undersigned Ampio Pharmaceuticals, Inc., a Delaware corporation (the “Maker”), issued one promissory note (the “Note”) in the amount of $200,000.00 each, and promised to pay to the order of DMI BioSciences, Inc., and its successors or assigns (collectively, the “Holder”), the aggregate sum of $200,000 due under the Note, together with interest at the rate of 6.0% (six percent) per annum until the Note is paid in full. The Note was originally due on September 2, 2010.

AMPIO PHARMACEUTICALS, INC. EXTENTION AGREEMENT FOR NOTES PAYABLE TOTAL PRINCIPAL AMOUNT: $100,000
Ampio Pharmaceuticals, Inc. • February 15th, 2011 • Pharmaceutical preparations

On August 10, 2010, the undersigned Ampio Pharmaceuticals, Inc., a Delaware corporation (the “Maker”), issued one promissory note (the “Note”) in the amount of $100,000.00, and promised to pay to the order of James Ludvik, and his successors or assigns (collectively, the “Holder”), the aggregate sum of $100,000.00 due under the Note, together with interest at the rate of 8.0% (eight percent) per annum until the Note is paid in full. The Note was originally due on January 31, 2011.

AMPIO PHARMACEUTICALS, INC. EXTENTION AGREEMENT FOR NOTES PAYABLE TOTAL PRINCIPAL AMOUNT: $100,000
Ampio Pharmaceuticals, Inc. • February 15th, 2011 • Pharmaceutical preparations

On August 10, 2010, the undersigned Ampio Pharmaceuticals, Inc., a Delaware corporation (the “Maker”), issued one promissory note (the “Note”) in the amount of $100,000.00, and promised to pay to the order of Richard B. Giles, and his successors or assigns (collectively, the “Holder”), the aggregate sum of $100,000.00 due under the Note, together with interest at the rate of 8.0% (eight percent) per annum until the Note is paid in full. The Note was originally due on January 31, 2011.

NOTE EXTENSION AND SUBORDINATION AGREEMENT
Note Extension and Subordination Agreement • February 15th, 2011 • Ampio Pharmaceuticals, Inc. • Pharmaceutical preparations

On November 12, 2009 and December 4, 2009, the undersigned DMI Life Sciences, Inc. , a Delaware corporation (the “Maker”), issued two promissory notes (the “Notes”) in the amount of $50,000.00 each, and promised to pay to the order of Michael Macaluso, and his successors or assigns (collectively, the “Holder”), the aggregate sum of $100,000 due under the Notes, together with interest at the rate of 6.0% (six percent) per annum until the Notes are paid in full. The Notes were originally due on April 30, 2010, and under a prior extension agreement were due on about September 1, 2010.

NOTE EXTENSION AND SUBORDINATION AGREEMENT
Extension and Subordination Agreement • February 15th, 2011 • Ampio Pharmaceuticals, Inc. • Pharmaceutical preparations

On November 6, 2009 and November 20, 2009, the undersigned DMI Life Sciences, Inc., a Delaware corporation (the “Maker”), issued two promissory notes (the “Notes”) in the amount of $50,000.00 each, and promised to pay to the order of DMI BioSciences, Inc., and its successors or assigns (collectively, the “Holder”), the aggregate sum of $100,000 due under the Notes, together with interest at the rate of 6.0% (six percent) per annum until the Notes are paid in full. The Notes were originally due on April 30, 2010, and under a prior extension agreement were due on about September 1, 2010.

AMPIO PHARMACEUTICALS, INC. EXTENTION AGREEMENT FOR NOTES PAYABLE TOTAL PRINCIPAL AMOUNT: $230,000
Extention Agreement • February 15th, 2011 • Ampio Pharmaceuticals, Inc. • Pharmaceutical preparations

On August 12, 2010 and August 16, 2010, the undersigned Ampio Pharmaceuticals, Inc., a Delaware corporation (the “Maker”), issued two promissory notes (the “Notes”) in the amounts of $30,000.00 and $200,000.00, respectively, and promised to pay to the order of Michael Macaluso, and his successors or assigns (collectively, the “Holder”), the aggregate sum of $230,000.00 due under the Notes, together with interest at the rate of 8.0% (eight percent) per annum until the Notes are paid in full. The Notes were originally due on January 31, 2011.

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