0001193125-11-047560 Sample Contracts

AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT
Loan and Security Agreement • February 25th, 2011 • Ista Pharmaceuticals Inc • Pharmaceutical preparations • Delaware

THIS AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT (this “Agreement”) dated as of the Effective Date between SILICON VALLEY BANK, a California corporation (“Bank”), and ISTA PHARMACEUTICALS, INC., a Delaware corporation (“Borrower”), amends, restates and supersedes (but does not act as a novation of) that certain Loan and Security Agreement dated as of December 16, 2005, and provides the terms on which Bank shall lend to Borrower and Borrower shall repay Bank. The parties agree as follows:

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FIRST AMENDMENT TO LEASE
Lease • February 25th, 2011 • Ista Pharmaceuticals Inc • Pharmaceutical preparations

This First Amendment to Lease (the “Amendment”) dated October 21, 2010, is by and between THE IRVINE COMPANY LLC, a Delaware limited liability company (Landlord’), and ISTA PHARMACEUTICALS, INC., a Delaware corporation (“Tenant”).

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