OREXIGEN THERAPEUTICS, INC. (a Delaware corporation) 5,646,173 Units Each Unit Consisting of One Share of Common Stock And A Warrant to Purchase Ten Shares of Common Stock PURCHASE AGREEMENTPurchase Agreement • December 15th, 2011 • Orexigen Therapeutics, Inc. • Pharmaceutical preparations • New York
Orexigen Therapeutics, Inc., a Delaware corporation (the “Company”) confirms its agreement with Leerink Swann LLC (“Leerink Swann”) and each of the other Underwriters named in Schedule A hereto (collectively, the “Underwriters,” which term shall also include any underwriter substituted as hereinafter provided in Section 10 hereof), for whom Leerink Swann is acting as representative (in such capacity, the “Representative”), with respect to the issue and sale by the Company and the purchase by the Underwriters, acting severally and not jointly, of the respective number of units set forth in said Schedule A (the “Units”), each of which Unit shall consist of (i) one share of Common Stock, par value $0.001 per share, of the Company (“Common Stock”) (such share of Common Stock constituting a part of the Units, collectively the “Shares”) and (ii) a warrant to purchase up to ten shares of Common Stock (such warrant constituting a part of the Units, collectively, the “Warrants” and together wit
