0001193125-12-107960 Sample Contracts

AMENDMENT TO CO-PROMOTION AGREEMENT
-Promotion Agreement • March 12th, 2012 • Zogenix, Inc. • Pharmaceutical preparations

THIS AMENDMENT TO CO-PROMOTION AGREEMENT (this “Amendment”) is entered into as of the 20th day of December, 2011, by and between Astellas Pharma US, Inc. (“Astellas”), and Zogenix, Inc. This Amendment amends that certain Co-Promotion Agreement dated as of July 31, 2009 (the “Agreement”), between the Parties (as defined in the Agreement).

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