0001193125-12-121673 Sample Contracts

MEDIVATION, INC. as Issuer AND WELLS FARGO BANK, NATIONAL ASSOCIATION as Trustee First Supplemental Indenture Dated as of March 19, 2012 to Indenture Dated as of March 19, 2012 2.625% Convertible Senior Notes due 2017

First Supplemental Indenture • March 19th, 2012 • Medivation, Inc. • Pharmaceutical preparations • New York

• Contract Type
  First Supplemental Indenture
• Filed
  March 19th, 2012
• Company
  Medivation, Inc.
• Industry
  Pharmaceutical preparations
• Jurisdiction
  New York

FIRST SUPPLEMENTAL INDENTURE, dated as of March 19, 2012, between Medivation, Inc., a corporation duly organized and existing under the laws of the State of Delaware, as issuer (the “Company”), having its principal office at 201 Spear Street, 3rd Floor, San Francisco, California 94105, and Wells Fargo Bank, National Association, a national banking association, as trustee (the “Trustee”) to the Indenture dated as of March 19, 2012, between the Company and the Trustee (the “Original Indenture”; the Original Indenture as amended and supplemented hereby and as it may be further amended and supplemented in accordance herewith and therewith, with respect to the Notes, the “Indenture”).

MEDIVATION, INC. Underwriting Agreement

Underwriting Agreement • March 19th, 2012 • Medivation, Inc. • Pharmaceutical preparations • New York

• Contract Type
  Underwriting Agreement
• Filed
  March 19th, 2012
• Company
  Medivation, Inc.
• Industry
  Pharmaceutical preparations
• Jurisdiction
  New York

Medivation, Inc. a Delaware corporation (the “Company”), proposes to issue and sell to the several Underwriters listed in Schedule 1 hereto (the “Underwriters”), for whom you are acting as representative (the “Representative”), the principal amount of its securities identified in Schedule 1 hereto (the “Underwritten Securities”) and, at the option of the Underwriters, up to an additional principal amount of securities set forth in Schedule 1 hereto to cover over-allotments (the “Option Securities”). The Underwritten Securities and the Option Securities are herein referred to as the “Securities.” The Securities are to be issued under an indenture dated as of March 19, 2012 (the “Base Indenture”), between the Company and Wells Fargo Bank, National Association, as trustee (the “Trustee”), as supplemented by the supplemental Indenture, dated as of March 19, 2012, between the Company and the Trustee (together with the Base Indenture, the “Indenture”) and will be convertible into shares (the