0001193125-12-341306 Sample Contracts

Contract
Adoption Agreement • August 7th, 2012 • Santarus Inc • Pharmaceutical preparations

NOTE: Execution of this Adoption Agreement creates a legal liability of the Employer with significant tax consequences to the Employer and Participants. Principal Life Insurance Company disclaims all liability for the legal and tax consequences which result from the elections made by the Employer in this Adoption Agreement.

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MANUFACTURING AND SUPPLY AGREEMENT
Manufacturing and Supply Agreement • August 7th, 2012 • Santarus Inc • Pharmaceutical preparations

THIS MANUFACTURING AND SUPPLY AGREEMENT (the “Agreement”) is made effective as of the 18th day of May 2012 (the “Effective Date”) by and between Santarus, Inc., a Delaware corporation, having offices at 3721 Valley Centre Drive, Suite 400, San Diego, California 92130, U.S.A. (“Santarus”) and COSMO Technologies Ltd, a company organised and existing under the laws of Ireland with principal offices and plant located at 42-43 Amiens Street, Dublin 1 Ireland (“Supplier”). Supplier and Santarus are sometimes referred to herein individually as a “Party” and collectively as the “Parties.”

Amendment to License Agreement Between Pharming Group N.V., Pharming Intellectual Property B.V. and Santarus, Inc.
License Agreement • August 7th, 2012 • Santarus Inc • Pharmaceutical preparations

This Amendment (the “Amendment”) to the License Agreement dated September 10, 2010 (the “License”), among Pharming Group N.V. on behalf of itself and each of its Affiliates, including Pharming Intellectual Property B.V. and Pharming Technologies B.V. (“Pharming”) and Santarus, Inc. (“Santarus”) is made as of June 18, 2012 (the “Effective Date”).

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