0001193125-12-358883 Sample Contracts

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ANGIOTECH PHARMACEUTICALS, INC., THE GUARANTORS named herein and DEUTSCHE BANK NATIONAL TRUST COMPANY, as Trustee SUPPLEMENTAL INDENTURE Dated as of August 13, 2012 TO INDENTURE Dated as of May 12, 2011 Senior Floating Rate Notes due 2013
Supplemental Indenture • August 16th, 2012 • Angiotech Pharmaceuticals Inc • Surgical & medical instruments & apparatus • New York

SUPPLEMENTAL INDENTURE dated as of August 13, 2012 (this “Supplemental Indenture”), to the Indenture dated as of May 12, 2011 (as amended, supplemented or otherwise modified from time to time, the “Indenture”) among Angiotech Pharmaceuticals, Inc., a corporation organized under the Business Corporation Act of the Province of British Columbia (the “Company”), the Guarantors (as defined in the Indenture) and Deutsche Bank National Trust Company, as trustee (the “Trustee”) under the Indenture. All capitalized terms used but not otherwise defined herein shall have the meaning assigned thereto in the Indenture.

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