0001193125-12-452123 Sample Contracts

Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Double asterisks denote omissions. LICENSE AND COLLABORATION AGREEMENT
License and Collaboration Agreement • November 5th, 2012 • Alnylam Pharmaceuticals, Inc. • Pharmaceutical preparations • New York

This LICENSE AND COLLABORATION AGREEMENT (this “Agreement”), is entered into as of August 27, 2012 (the “Effective Date”), by and among Monsanto Company, a Delaware corporation, having a place of business at 800 N. Lindbergh Blvd., St. Louis, Missouri 63167, U.S.A. (“Monsanto”), and Alnylam Pharmaceuticals, Inc., a Delaware corporation, having a place of business at 300 Third Street, 3rd Floor, Cambridge, Massachusetts 02142, U.S.A. (“Alnylam”).

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Novartis Pharma AG Lichtstrasse 35 4056 Basel, Switzerland
Alnylam Pharmaceuticals, Inc. • November 5th, 2012 • Pharmaceutical preparations • Delaware

Reference is made to the Investor Rights Agreement, dated September 6, 2005, by and between Alnylam Pharmaceuticals, Inc., a Delaware corporation (the “Company”), and Novartis Pharma AG, a corporation organized under the laws of Switzerland (“Novartis,” and together with the Company, the “Parties”) (the “Investor Rights Agreement”).

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