0001193125-12-507514 Sample Contracts

REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • December 19th, 2012 • ARCA Biopharma, Inc. • In vitro & in vivo diagnostic substances • New York

This REGISTRATION RIGHTS AGREEMENT (this “Agreement”), dated as of December , 2012, is by and among ARCA biopharma, Inc., a Delaware corporation (the “Company”), and the undersigned buyer ( “Buyer”).

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SUBSCRIPTION AGREEMENT
Subscription Agreement • December 19th, 2012 • ARCA Biopharma, Inc. • In vitro & in vivo diagnostic substances • New York

This Subscription Agreement (the “Agreement”) is dated as of December [ ], 2012 (the “Effective Date”), between ARCA biopharma, Inc., a Delaware corporation (the “Company”), and the Purchaser identified on the signature page hereto (the “Purchaser”).

AMENDMENT TO THE REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • December 19th, 2012 • ARCA Biopharma, Inc. • In vitro & in vivo diagnostic substances • New York

This Amendment to that certain Registration Rights Agreement dated October 25, 2012 (the “Registration Rights Agreement”) is made and entered into this 18th day of December, 2012 between ARCA biopharma, Inc., a Delaware corporation (the “Company”), and the other parties identified on the signature page hereto (the “Buyers”).

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