0001193125-13-112709 Sample Contracts

Amendment No. 2 to LICENSE AGREEMENT
License Agreement • March 18th, 2013 • Omeros Corp • Pharmaceutical preparations

This Amendment No. 2 to License Agreement (this “Amendment No. 2”) is made effective the 25 day of January 2013 (the “Effective Date”) between Daiichi Sankyo Company, Limited, a Japanese Corporation having a place of business at 5-1, Nihonbashi Honcho 3-Chome, Chuo-ku, Tokyo 103-8426 Japan (“DS”), and Omeros Corporation, a Washington corporation having a principal place of business at 1420 Fifth Avenue, Suite 2600, Seattle, WA 98101 USA (“Omeros”).

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FIFTH AMENDMENT TO LOAN AND SECURITY AGREEMENT
Loan and Security Agreement • March 18th, 2013 • Omeros Corp • Pharmaceutical preparations

THIS FIFTH AMENDMENT to Loan and Security Agreement (this “Amendment”) is entered into as of July 23, 2012, by and between OXFORD FINANCE LLC (“Lender”) and OMEROS CORPORATION, a Washington corporation (“Borrower”) whose address is 1420 5th Avenue, Suite 2600, Seattle, WA 98101.

FOURTH AMENDMENT TO LOAN AND SECURITY AGREEMENT
Loan and Security Agreement • March 18th, 2013 • Omeros Corp • Pharmaceutical preparations

THIS FOURTH AMENDMENT to Loan and Security Agreement (this “Amendment”) is entered into as of February 1, 2012, by and between OXFORD FINANCE LLC (successor in interest to Oxford Finance Corporation; “Lender”) and OMEROS CORPORATION, a Washington corporation (“Borrower”) whose address is 1420 5th Avenue, Suite 2600, Seattle, WA 98101.

SECOND AMENDMENT TO LEASE
Lease • March 18th, 2013 • Omeros Corp • Pharmaceutical preparations
THIRD AMENDMENT TO LOAN AND SECURITY AGREEMENT
Loan and Security Agreement • March 18th, 2013 • Omeros Corp • Pharmaceutical preparations

THIS THIRD AMENDMENT to Loan and Security Agreement (this “Amendment”) is entered into as of June 13, 2011, by and between OXFORD FINANCE LLC (successor in interest to Oxford Finance Corporation; “Lender”) and OMEROS CORPORATION, a Washington corporation (“Borrower”) whose address is 1420 5th Avenue, Suite 2600, Seattle, WA 98101.

FIRST AMENDMENT TO PATENT ASSIGNMENT AGREEMENT
Patent Assignment Agreement • March 18th, 2013 • Omeros Corp • Pharmaceutical preparations

This first amendment (the “Amendment”) effective 31 December 2010 is made to the patent assignment dated the 23rd day of February 2009 (the “Assignment Agreement”) between Omeros Corporation, a Washington corporation having a principal place of business at 1420 Fifth Avenue, Suite 2600, Seattle WA 98101 USA (“Omeros”) and Roberto Ciccocioppo, Ph.D., having a residence at Vicolo San Silvestro n. 25, Camerino, 62032 IT (“Dr. Ciccocioppo”).

CONSENT AND FIRST AMENDMENT TO LOAN AND SECURITY AGREEMENT
Loan and Security Agreement • March 18th, 2013 • Omeros Corp • Pharmaceutical preparations

THIS CONSENT AND FIRST AMENDMENT to Loan and Security Agreement (this “Amendment”) is entered into as of February 3, 2011, by and between OXFORD FINANCE CORPORATION (“Lender”) and OMEROS CORPORATION, a Washington corporation (“Borrower”) whose address is 1420 5th Avenue, Suite 2600, Seattle, WA 98101.

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