AMENDMENT NO. 1 TO MANUFACTURING SERVICES AGREEMENT NOVEMBER 1, 2013Manufacturing Services Agreement • March 13th, 2014 • Orexigen Therapeutics, Inc. • Pharmaceutical preparations • Ontario
This Amendment No. 1 is intended to modify the MANUFACTURING SERVICES AGREEMENT (the “Agreement”) dated March 12, 2010 by and between OREXIGEN THERAPEUTICS, INC., a corporation existing under the laws of the State of Delaware (“Client”), and Patheon Pharmaceuticals Inc., a corporation existing under the laws of the State of Delaware, and Patheon Inc., a corporation existing under the laws of Canada (collectively, “Patheon”). All capitalized terms used herein and not otherwise defined will have the meanings assigned to such terms in the Agreement.
NALTREXONE HYDROCHLORIDE SUPPLY AGREEMENTNaltrexone Hydrochloride Supply Agreement • March 13th, 2014 • Orexigen Therapeutics, Inc. • Pharmaceutical preparations • New York
This Naltrexone Hydrochloride Supply Agreement (this “Agreement”) is made effective as of January 1, 2013 (the “Effective Date”) by and among OREXIGEN THERAPEUTICS, INC. (“OREXIGEN”), a Delaware corporation located at 3344 N. Torrey Pines Court, Suite 200, La Jolla, CA 92037, and MALLINCKRODT LLC (“MALLINCKRODT”), a Delaware limited liability company located at 675 McDonnell Blvd., Hazelwood, Missouri 63042.
AMENDMENT NUMBER 1 TO COLLABORATION AGREEMENTCollaboration Agreement • March 13th, 2014 • Orexigen Therapeutics, Inc. • Pharmaceutical preparations
This AMENDMENT NUMBER 1 TO COLLABORATION AGREEMENT (the “Amendment No. 1”) is made and entered into as of September 26, 2013 (the “Amendment No. 1 Effective Date”), by and between Orexigen Therapeutics, Inc., a Delaware corporation located at 3344 N. Torrey Pines Court, Suite 200, La Jolla, California 92037, United States of America (“Orexigen”), and Takeda Pharmaceutical Company Limited, a Japanese corporation with a principal place of business at 1-1, Doshomachi 4-Chome Chuo-ku, Osaka 540-8645, Japan (“Takeda”). Orexigen and Takeda are sometimes referred to herein individually as a “Party” and collectively as the “Parties.”
