0001193125-14-197413 Sample Contracts

Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Double asterisk denote omissions. Amendment to Collaboration and License Agreement
Collaboration and License Agreement • May 14th, 2014 • Epizyme, Inc. • Pharmaceutical preparations

This Amendment No. 4 (this “Amendment No. 4”) to the Collaboration and License Agreement dated as of January 8, 2011 and previously amended on July 23, 2013, February 24, 2014, and March 18, 2014 (as so amended, the “Agreement”), by and between EPIZYME and GSK is effective as of April 17, 2014 (the “Amendment Effective Date”). Capitalized terms used but not defined herein shall have the meanings ascribed to such terms in the Agreement.

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