0001193125-15-088459 Sample Contracts

Amendment No. 5 to Collaboration and License Agreement
Collaboration and License Agreement • March 12th, 2015 • Epizyme, Inc. • Pharmaceutical preparations

This Amendment (this “Amendment”) to the Collaboration and License Agreement dated as of January 8, 2011, as amended from time to time (the “Agreement”), by and between EPIZYME and GSK is effective as of the 1st day of October, 2014 (the “Amendment Effective Date”). Capitalized terms used but not defined herein shall have the meanings ascribed to such terms in the Agreement.

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FIRST AMENDMENT TO THE CONSULTING AGREEMENT
Consulting Agreement • March 12th, 2015 • Epizyme, Inc. • Pharmaceutical preparations

THIS FIRST AMENDMENT TO THE CONSULTING AGREEMENT (“Amendment No. 1”) is made effective as of December 19, 2014 (the “Amendment No. 1 Effective Date”) by and between Epizyme, Inc., with a principal business address at 400 Technology Square, 4th Floor, Cambridge, Massachusetts 02139 (“Epizyme”) and Eric Hedrick (“Consultant”).

EPIZYME, INC. RESTRICTED STOCK UNIT AGREEMENT
Restricted Stock Unit Agreement • March 12th, 2015 • Epizyme, Inc. • Pharmaceutical preparations • Delaware

Epizyme, Inc. (the “Company”) has selected you to receive an award of restricted stock units (“RSUs”) pursuant to the Company’s 2013 Stock Incentive Plan (the “Plan”). The terms and conditions attached hereto are also a part hereof. Terms used in this Agreement which are not defined in this Agreement shall have the meanings used or defined in the Plan.

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