0001193125-15-178432 Sample Contracts

AMENDMENT TO THE RESEARCH COLLABORATION AND LICENSE AGREEMENT
Research Collaboration and License Agreement • May 8th, 2015 • Alnylam Pharmaceuticals, Inc. • Pharmaceutical preparations • Massachusetts

This Amendment to the Research Collaboration and License Agreement (this “Amendment”) is entered into as of February 27, 2015, by and between Novartis Institutes for BioMedical Research, Inc., a corporation organized and existing under the laws of Delaware, with its principal place of business at 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, and Alnylam Pharmaceuticals, Inc., a corporation organized and existing under the laws of Delaware, with its principal place of business at 300 Third Street, 3rd Floor, Cambridge, Massachusetts 02142.

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SECOND AMENDED AND RESTATED STRATEGIC COLLABORATION AND LICENSE AGREEMENT
Strategic Collaboration And • May 8th, 2015 • Alnylam Pharmaceuticals, Inc. • Pharmaceutical preparations • Delaware

This Second Amended and Restated Strategic Collaboration and License Agreement (the “Agreement”) is executed this January 8, 2015 (the “Second Restatement Date”), between Isis Pharmaceuticals, Inc., a Delaware corporation having an address at 2855 Gazelle Court, Carlsbad, CA 92010 (“Isis”) and Alnylam Pharmaceuticals, Inc., a Delaware corporation having an address at 300 Third Street, Cambridge, MA 02142 (“Alnylam”). Isis and Alnylam may be referred to herein as the “Parties,” or each individually as a “Party.”

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