0001193125-15-336549 Sample Contracts

PROQR THERAPEUTICS N.V. Ordinary Shares (nominal value €0.04 per share) Controlled Equity OfferingSM Sales Agreement
Sales Agreement • October 2nd, 2015 • ProQR Therapeutics N.V. • Pharmaceutical preparations • New York

ProQR Therapeutics N.V., a Dutch public company with limited liability (the “Company”), confirms its agreement (this “Agreement”) with Cantor Fitzgerald & Co. (the “Agent”), as follows:

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