0001193125-16-493375 Sample Contracts

AMENDMENT NUMBER ONE TO TERMINATION AGREEMENT AND TO MANUFACTURING AND SUPPLY AGREEMENT
Termination Agreement • March 4th, 2016 • Ardelyx, Inc. • Pharmaceutical preparations • Delaware

This Amendment Number One to Termination Agreement and to Manufacturing and Supply Agreement (this “Amendment Number One”) is entered into as of the 2nd day of November, 2015 (the “Amendment Number One Effective Date”) by and between AstraZeneca AB (publ), a Swedish corporation with corporate identity no. 556011-7482 and a place of business at 431 83 Mölndal, Sweden (“AstraZeneca”) and Ardelyx, Inc., a Delaware corporation having its principal place of business at 34175 Ardenwood Boulevard, Fremont, California, United States of America 94555 (“Ardelyx”). Ardelyx and AstraZeneca are sometimes referred to herein individually as a “Party” and collectively as the “Parties.”

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