0001193125-16-637253 Sample Contracts

ARRANGEMENT AGREEMENT BY AND AMONG OPKO HEALTH, INC., OPKO GLOBAL HOLDINGS, INC. AND TRANSITION THERAPEUTICS INC. Dated as of June 29, 2016
Arrangement Agreement • June 30th, 2016 • Opko Health, Inc. • Pharmaceutical preparations • Ontario

THIS ARRANGEMENT AGREEMENT (this “Agreement”) is made and entered into as of June 29, 2016, by and among OPKO HEALTH, INC., a Delaware corporation (“Parent”); OPKO GLOBAL HOLDINGS, INC., a corporation incorporated under the laws of the Cayman Islands (“CaymanCo”); and TRANSITION THERAPEUTICS INC., a corporation incorporated under the laws of Ontario (the “Company”). Certain capitalized terms used in this Agreement are defined in Section 8.1.

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