EXPRESS SCRIPTS HOLDING COMPANY $1,000,000,000 3.000% Senior Notes Due 2023 $1,500,000,000 3.400% Senior Notes Due 2027 $1,500,000,000 4.800% Senior Notes Due 2046 UNDERWRITING AGREEMENTUnderwriting Agreement • July 5th, 2016 • Express Scripts Holding Co. • Retail-drug stores and proprietary stores • New York
