0001193125-16-674184 Sample Contracts

TWENTY-THIRD SUPPLEMENTAL INDENTURE
Twenty-Third Supplemental Indenture • August 8th, 2016 • Alere Inc. • In vitro & in vivo diagnostic substances • New York

WHEREAS the Issuer has heretofore executed and delivered an Indenture dated as of May 12, 2009, as amended, supplemented and modified by a Sixteenth Supplemental Indenture dated as of May 24, 2013, an Eighteenth Supplemental Indenture dated as of June 5, 2014, and a Twentieth Supplemental Indenture dated as of October 30, 2014 (as so amended, supplemented and modified, and as further amended, supplemented or modified to date, the “Indenture”), by and among the Issuer, the Existing Guarantors and the Trustee, providing for the issuance of 6.50% Senior Subordinated Notes due 2020 (the “Notes”);

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NINETEENTH SUPPLEMENTAL INDENTURE
Supplemental Indenture • August 8th, 2016 • Alere Inc. • In vitro & in vivo diagnostic substances • New York

WHEREAS the Issuer has heretofore executed and delivered an Indenture dated as of August 11, 2009, as amended, supplemented and modified by a Fifteenth Supplemental Indenture dated as of December 11, 2012, a Sixteenth Supplemental Indenture dated as of April 3, 2013, a Seventeenth Supplemental Indenture dated as of June 5, 2014, and an Eighteenth Supplemental Indenture dated as of October 30, 2014 (as so amended, supplemented and modified, and as further amended, supplemented or modified to date, the “Indenture”), by and among the Issuer, the Existing Guarantors and the Trustee, providing for the issuance of 7.250% Senior Notes due 2018 (the “Notes”);

TWENTY-SECOND SUPPLEMENTAL INDENTURE
Supplemental Indenture • August 8th, 2016 • Alere Inc. • In vitro & in vivo diagnostic substances • New York

WHEREAS the Issuer has heretofore executed and delivered an Indenture dated as of May 12, 2009, as amended, supplemented and modified by a Twenty-First Supplemental Indenture dated as of June 24, 2015 (as so amended, supplemented and modified, and as further amended, supplemented or modified to date, the “Indenture”), by and among the Issuer, the Existing Guarantors and the Trustee, providing for the issuance of 6.375% Senior Subordinated Notes due 2023 (the “Notes”);

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