0001193125-16-675135 Sample Contracts

ARDELYX, INC. SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • August 8th, 2016 • Ardelyx, Inc. • Pharmaceutical preparations • California

This Securities Purchase Agreement (“Agreement”) is made as of July 14, 2016 (the “Effective Date”), by and among Ardelyx, Inc., a Delaware corporation (the “Company”), each of those persons and entities, severally and not jointly, listed as a Purchaser on the Schedule of Purchasers attached as Exhibit A hereto (the “Schedule of Purchasers”) and Future Fund Investment Company No. 4 Pty Ltd, a proprietary limited company organized under the laws of Australia (the “FF Beneficial Investor”).

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THIRD AMENDMENT TO LEASE
Lease • August 8th, 2016 • Ardelyx, Inc. • Pharmaceutical preparations

THIS THIRD AMENDMENT TO LEASE (this “Third Amendment”) is entered into as of this 28th day of April, 2016 (the “Execution Date”), by and between 34175 ARDENWOOD VENTURE, LLC, a Delaware limited liability company (“Landlord”), and ARDELYX, INC., a Delaware corporation (“Tenant,” formerly known as Nteryx, Inc.).

REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • August 8th, 2016 • Ardelyx, Inc. • Pharmaceutical preparations • California

This Registration Rights Agreement (this “Agreement”) is made and entered into as of July 14, 2016, by and among Ardelyx, Inc., a Delaware corporation (the “Company”), Future Fund Investment Company No.4 Pty Ltd, a proprietary limited company organized under the laws of Australia (the “FF Beneficial Investor”), The Northern Trust Company in its capacity as custodian (the “FF Investor”) for the FF Beneficial Investor, and each of the other parties signatory hereto (such other parties and the FF Investor, each a “Purchaser” and together, the “Purchasers”).

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