0001193125-16-680807 Sample Contracts

RESTRICTED STOCK SUBSTITUTION AGREEMENT
Restricted Stock Substitution Agreement • August 12th, 2016 • Acucela Japan KK • Pharmaceutical preparations • Tokyo

This Restricted Stock Substitution Agreement (the “Agreement”) is made and entered into as of [Month, Date], [Year], by and between Kubota Pharmaceutical Holdings Co., Ltd., a Japanese corporation (the “Company”), and [Name] (the “Holder”).

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STOCK OPTION SUBSTITUTION AGREEMENT
Stock Option Substitution Agreement • August 12th, 2016 • Acucela Japan KK • Pharmaceutical preparations

This Stock Option Substitution Agreement (the “Agreement”) is made and entered into as of [Month, Date], [Year], by and between Kubota Pharmaceutical Holdings Co., Ltd., a Japanese corporation (the “Company”), and [Name] (the “Holder”).

RESTRICTED STOCK UNIT SUBSTITUTION AGREEMENT
Restricted Stock Unit Substitution Agreement • August 12th, 2016 • Acucela Japan KK • Pharmaceutical preparations

This Restricted Stock Unit Substitution Agreement (the “Agreement”) is made and entered into as of [Month, Date], [Year], by and between Kubota Pharmaceutical Holdings Co., Ltd., a Japanese corporation (the “Company”), and [Name] (the “Holder”).

Liability Limitation Agreement
Liability Limitation Agreement • August 12th, 2016 • Acucela Japan KK • Pharmaceutical preparations

Kubota Pharmaceutical Holdings Co., Ltd. (the “Company”) and [TBD] (“Director”) enter into this agreement (this “Agreement”) as follows in accordance with Article 427, Paragraph 1 of the Companies Act and Article 26, Paragraph 2 of the Articles of Incorporation of the Company.

ACUGEN NEUROPEUTICS INC.
Nonstatutory] Stock Option Agreement • August 12th, 2016 • Acucela Japan KK • Pharmaceutical preparations

Acugen Neuropeutics Inc., a Washington corporation (the “Company”), hereby grants an Option to purchase shares of its common stock (the “Shares”) to the Optionee named below. The terms and conditions of the Option are set forth in this cover sheet, in the attachment and in the Company’s 2002 Stock Option and Restricted Stock Plan (the “Plan”).

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