0001193125-16-759107 Sample Contracts

October 1, 2016 Michael Lewis, Ph.D. Bio Diligence Partners, Inc.,
Services Agreement • November 4th, 2016 • Cara Therapeutics, Inc. • Pharmaceutical preparations

This letter shall serve as a twelfth amendment to the Services Agreement dated July 2, 2004. It is hereby agreed to extend the Agreement from October 1, 2016 to July 1, 2017. Compensation described in Exhibit A of the Agreement, as previously amended, will continue at the rate of $157,500.00 per annum and paid on a monthly basis. The reimbursement for 100% of the health insurance cost shall continue, paid quarterly.

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