0001193125-17-084396 Sample Contracts

First Amendment to Letter Agreement
Letter Agreement • March 16th, 2017 • Karyopharm Therapeutics Inc. • Pharmaceutical preparations

First Amendment (“Amendment”) made as of October 4, 2016, to that certain letter agreement (the “Employment Agreement”) dated June 7, 2015, by and between Karyopharm Therapeutics Inc., a Delaware Corporation (the “Company”), and Ran Frenkel setting forth the terms of Mr. Frenkel’s employment with the Company as Chief Development Operations Officer.

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