0001193125-17-087159 Sample Contracts

PFIZER INC. and THE BANK OF NEW YORK MELLON, Trustee THE BANK OF NEW YORK MELLON, LONDON BRANCH, Paying Agent EIGHTH SUPPLEMENTAL INDENTURE Dated as of March 17, 2017 to INDENTURE Dated as of January 30, 2001 4.20% Notes due 2047
Eighth Supplemental Indenture • March 17th, 2017 • Pfizer Inc • Pharmaceutical preparations • New York

EIGHTH SUPPLEMENTAL INDENTURE, dated as of March 17, 2017 (the “Eighth Supplemental Indenture”), among Pfizer Inc., a corporation duly organized and existing under the laws of the State of Delaware, having its principal office at 235 East 42nd Street, New York, New York 10017 (the “Company”), The Bank of New York Mellon (formerly The Bank of New York, a New York banking corporation (successor to JPMorgan Chase Bank, N.A. (formerly JPMorgan Chase Bank, formerly The Chase Manhattan Bank (successor to The Chase Manhattan Bank (National Association)))), as trustee (the “Trustee”) and The Bank of New York Mellon, London Branch, as paying agent.

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